INTRODUCTION

You may have heard about Polynucleotides, the skin boosting and regenerative injectables that have been trending in recent months. They’ve started revolutionising the aesthetics and skincare industry and have become an increasingly popular solution amongst patients for treating the signs of ageing and other common skin complaints – for good reason. If you haven’t heard about them yet, don’t worry. We’ll break down exactly what polynucleotides are, what benefits they have, and what makes them unique from other anti-ageing treatments.

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WHAT ARE POLYNUCLEOTIDES?

Polynucleotides are an injectable skin treatment which is designed to help tissue repair. It improves skin quality, thickness, hydration, and promotes new collagen formation.

This polymerised, polynucleotide-based injectable gel works by stimulating fibroblasts, encouraging cell turnover, improving elasticity, boosting collagen production and hydrating the skin.

It is a highly versatile product which has a host of potential applications, including treatment for acne scarring, hyperpigmentation, and rosacea as well as the signs of ageing.

In addition to treatments for the upper, mid and lower face, Polynucleotides can also be used to treat the neck, décolletage, inner arms, thighs, and knees. It will also be particularly useful for difficult areas such as the neck and beneath the eyes.

Polynucleotides are a component predominantly derived from salmon DNA, making them natural, compatible and biodegradable. Dr Bob Khanna explains that polynucleotides are “like food or medicine for cells, making them produce collagen and elastin and helping to improve the extracellular matrix” (that’s the structural support layer within our skin that keeps us looking youthful, containing those fibrous elements such as collagen, elastic etc).

Sometimes, Polynucleotides treatments can be referred to as Biostimulators, Biofillers, or Biorevitalisers (depending on the manufacturer and composition), but they all contain the core anti-ageing ingredient; polynucleotides.

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BENEFITS

• Stimulate and boost collagen and elastin production

• Durably and efficiently repair the skin (and hair) at a cellular level

• Hydrate the skin at a cellular level

• Improve tissue firmness and elasticity

• Have anti-inflammatory properties

• Promote cellular renewal

• Lifting and tightening the skin

• Improving skin texture and smoothness

• Brightening the skin

• Increasing volume within the skin

• Minimising acne scars

• Minimising stretch marks

• Minimising/restoring hair loss

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​With many people seeking more natural solutions for their cosmetic procedures polynucleotide treatment is having a bit of a moment and is becoming increasingly popular in aesthetic clinics. Polynucleotide treatment uses DNA fragments extracted from salmon to bio-stimulate positive changes in the skin. Polynucleotide solution has the capability to send specific signals to the skin at a cellular level to bring about the actions we would like it to perform, so when it is injected into the skin, research studies have shown the following effects:

• 115% increase in skin hydration

• Over 50% increase in skin thickness

• 47% increase in collagen production

• 38% increase in skin elasticity

• Reduction in inflammatory redness and improvement in rosacea and acne

• Improvement in acne scarring

• Reduction in pigmentation resulting from sun exposure

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Polynucleotides vs. Traditional Injectable anti-ageing treatments

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Fix not fill

Unlike dermal fillers, which are designed to temporarily plump the skin, Polynucleotides have been scientifically proven to regenerate the skin from inside, at a cellular level, increasing your skin’s hydration levels, collagen production, skin elasticity and more. Some Polynucleotide products are combined with hyaluronic acid for added volume.

See results quicker

Unlike other anti-ageing treatments such as skin boosters that typically take around 3 months to see improvements, improvements in skin quality from polynucleotide treatments can be seen in just a few weeks (or when combined with hyaluronic acid, results can be seen instantly).

They go deeper than other treatments 

By far, the most popular solution for the signs of ageing has been anti-wrinkle injections, (commonly known as ‘botox’). Whilst this still maintains status as an effective anti-ageing solution, the average treatment lasts around an average of 3-4 months. Most polynucleotide treatments are designed to last 6-12 months, with the effects also continuing to improve the underlying skin quality long after that.

Previously, the most effective injectable for skin rejuvenation we had was known as a “skin booster”. This is a type of dermal filler used to improve the skin’s quality by boosting hydration levels deep within the skin. Our new biostimulators (polynucleotide treatments) go even further, not just increasing hydration levels deep within, but also acting as a skin healer. Polynucleotides compliment the skin’s natural ability to self-repair by interacting directly with the fibroblasts and cells.

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HOW ARE POLYNUCLEOTIDES DIFFERENT TO DERMAL FILLERS?

Dermal fillers are usually made from a synthetic version of hyaluronic acid and act as 'implants' in the skin to volumise, hydrate and improve skin folds, wrinkles etc. Whilst dermal fillers can be amazing for some skin concerns there are occasions when a dermal filler is not the right choice and polynucleotides are more appropriate. For example, many people seek tear trough treatment for a tired, hollow undereye area but they may not be suitable for dermal filler. This may be because the hollowness is not deep enough, or the skin is too thin, they have dark circles or they have some undereye puffiness. So for these individuals who are not suitable for tear trough treatment, polynucleotide treatment may be much more appropriate. Another example would be someone who had some skin laxity (loose skin) but does not require volumisation - polynucleotide treatment would help to firm and restore the skin without the addition of unnecessary volume.

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CAN POLYNUCLEOTIDE TREATMENT BE COMBINED WITH OTHER TREATMENTS?

Absolutely! In fact, we often recommend it for best results. We often pair polynucleotide treatment with dermal fillers, anti-wrinkle injections, Microneedling or Profhilo as we find that combination treatments yield the best results.

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​CONTRAINDICATIONS 

Not everyone is a suitable candidate for Polynucleotides. Contraindications may include:

• Pregnancy and Breastfeeding: Polynucleotides are generally avoided during pregnancy and breastfeeding.

• Active Skin Infections: Individuals with active skin infections should postpone treatment until the infection has cleared.

• Allergies: If you have known allergies to any of the components of skin boosters, it's essential to discuss this with your healthcare provider.

• Autoimmune Conditions: Patients with certain autoimmune diseases may need to consult with their healthcare provider before considering Polynucleotides treatments.

• Medications: Some medications may interact with Polynucleotides, so it's crucial to inform your practitioner about your medical history and current medications.

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SIDE AFFECTS

Like any medical procedure, Polynucleotides treatments may have potential side effects, although these are generally mild and temporary. They may include:

• Redness: Some redness at the injection site is common and typically resolves within a day or two.

• Swelling: Mild swelling may occur but usually subsides within a few days.

• Bumps: You will be left with small bumps all over the treated area. This can take anywhere from 12-36 hours to settle.

• Bruising: Occasionally, patients may experience bruising, which can be covered with makeup and tends to fade within a week.

• Tenderness: The treated area may feel slightly tender or sore, but this discomfort should be short-lived.

• Itching: Some patients may experience temporary itching at the injection sites.

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THE TREATENT PROCESS

If you're considering a Polynucleotides treatment, it's essential to understand the treatment process to ensure a safe and effective experience. Here's a step-by-step overview of what to expect during a typical Polynucleotides treatment:

Consultation:

• Your Polynucleotides journey begins with an initial consultation. During this consultation, you'll discuss your skincare goals, concerns, medical history, and the type of Polynucleotides that's most suitable for your needs.

• We will assess your skin's condition, identifying specific areas that require improvement and tailoring the treatment plan to address your unique concerns.

Pre-Treatment Preparation:

• On the day of your treatment, we will ensure your skin is clean and free of makeup or lotions.

• Topical numbing cream may be applied to the treatment area to minimize any discomfort during the procedure. In some cases, cooling techniques, like ice packs, can also be used to ease discomfort.

Injection Process:

• We will use a fine needle or microcannula to inject the Polynucleotides solution into the targeted areas of your skin. The choice of injection method will depend on the specific Polynucleotides used and the treatment goals.

• The injections are typically quick and precise, often completed within 30 minutes.

• You may feel some minor discomfort, such as a slight stinging or pressure sensation, but the numbing cream and cooling techniques help minimize any pain.

Post-Treatment Care:​

• Post-treatment instructions, include avoiding sun exposure, saunas, steam rooms, excessive exercise, touching the area, makeup, and certain skincare products for 48 hours following the procedure.

• Drink plenty of water and stay well hydrated.

Immediate Results:

• Polynucleotides treatments provide immediate hydration and a refreshed appearance to your skin, but the full effects may develop over the course of a few weeks as the skin's collagen production is stimulated.

Follow-Up Appointments:

• Three to four sessions, spaced over 21-28 days are required for best results. We recommend 2 treatments initially (2-4 weeks apart) with a top-up session if required.

Maintenance:

• Maintenance treatments are recommended around every 6-9 months to maintain the results. Unlike dermal fillers which offer instant results, polynucleotide treatment requires some patience. Your skin quality will improve gradually as the tissues regenerate. You’ll definitely notice the difference after 2-4 weeks, but things will continue to improve as this is a regenerative treatment. Full results can be expected about 3 months after treatment. 

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In conclusion, polynucleotide treatments are a safe and effective way to rejuvenate and enhance your skin's quality and appearance. When administered by a qualified and skilled practitioner, these treatments can deliver excellent results, leaving your skin looking fresh, radiant, and revitalized.